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Polyunsaturated fatty acids reduce fatty acid synthase and hydroxy-methyl-glutaryl CoA-reductase gene expression and promote apoptosis in HepG2 cell line

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Recently, intermolecular contact formed by brazilein, identified as an oxidized form of brazilin (neoflavonoid), via copper chelation along with hydrophobic and hydrogen bonding in the catalytic core of tyrosinase was established to induce structural variations in the secondary structure of the protein 83