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Two phase 3 trials BLOOM (Behavioral modification and Lorcaserin for Overweight and Obesity Management) and BLOSSOM (Behavioral modification and LOrcaserin Second Study for Obesity Management) evaluated obese and overweight patients to demonstrate the efficacy of lorcaserin (10 mg twice daily) over placebo [83.84]

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Additional contributors include ROS and nitric oxide (NO), which induce oxidative stress and trigger both caspase-dependent and caspase-independent apoptosis (Xiao et al., 2023)