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(2016) determined the methanol extraction process of baicalin by orthogonal experiment: 70% methanol was refluxed and extracted three times at 80 °C, the ratio of material to liquid was 1:8,1:6,1:4, and the time was 2h, 2h, 1h, respectively

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In ADC design, the type and properties of the linker are key factors that determine whether the drug can achieve clinical success