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As islets are depolarized by external glucose, the NMDA-R-mediated repolarization of the beta cells is a negative feedback regulation of glucose-stimulated insulin secretion

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The Phase 3 ophthalmic program (RGN-259) comprises three completed dry-eye trials (ARISE-1 n=317, ARISE-2 n=601, ARISE-3 n=700) and one completed European neurotrophic keratopathy trial (SEER-3), all of which missed their pre-specified primary endpoints