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In fruit flies and rats, some studies observed a reduction in age-related mortality indices, and in specific mouse strains predisposed to cardiovascular and oncologic conditions, trends toward longer survival were reported under defined conditions

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This rationale may also explain the high incidence of autoimmune disease in the period after cure of hypercortisolism and during the postpartum period, as well as in untreated or under-replaced adrenal insufficiency [224]