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Nanovesicles engineered for surface Tf-Fe³⁺ display and SOR encapsulation (SOR@TF-Fe³⁺ NVs) achieved TfR-directed HCC targeting, enhancing tumoral iron/SOR accumulation and ferroptosis induction while maintaining favorable liver distribution [177]

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Additionally, B12 is vital for DNA synthesis, cell division, and energy metabolism, helping to reduce fatigue