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These alterations in metabolic pathways, resulted in a significant decline in the levels of aspartate, uracil, serine, sarcosine, arginine, dehydroalanine, thymine, and porphobilinogen in LC patients versus HCs ( Figure 3B , Supplementary Figure 3A )
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In 2019, the multi-source analysis conducted by the CRPV [Centre Regional de Pharmacovigilance (French Regional Pharmacovigilence Centre)], which integrated complementary pharmacological data (clinical, pharmacoepidemiological, and experimental), confirmed and amplified the conclusions of the previous reports on the role of NSAIDs (in case of particularly ibuprofen, ketoprofen) in the aggravation of bacterial infections particularly in pulmonary infections 94