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DECLARATIONS Authors’ contributions Conceived the review, drafted the manuscript, and secured funding: Fanzani A Contributed to conceptualization, prepared the figures and tables, and critically revised the manuscript: Codenotti S Performed the literature search: Cattaneo CG Critically reviewed and revised the manuscript: Megiorni F, Gastaldello S, Pozzo E, Sampaolesi M, Rota R, Keller C Critically revised the manuscript and secured funding: Marampon F Availability of data and materials Not applicable

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, dorsal thalamus, hippocampus, lateral geniculate body, hypothalamus, dorsal raphe nucleus, substantia nigra, medial anterior olfactory nucleus, lateral caudate, accumbens nucleus, superior olive)) (shown by the very precise alpha-[14C]methyl-L-tryptophan (alpha-MTrp) autoradiographic method) (16, 20)