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Oral formulations, while convenient, require 3-5 times higher doses due to extensive first-pass metabolism and have shown inconsistent results in cell culture studies [4]

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The medullary tissue is composed of unique postganglionic SNS neurons called chromaffin cells, which are large and irregularly shaped, and produce the neurotransmitters epinephrine (also called adrenaline) and norepinephrine (or noradrenaline)