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Followed by directed evolution, the resulting enzyme (BH32_H23NMH_L10P_A19H_S22M_E46N_P63G_C125G) obtained capability of accelerating fluoresceinyl ester hydrolysis with an extraordinary efficiency of over 9000-fold improvement compared to free NMH in solution (Figure 8a)

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Detailed Description Epithalon is a tetrapeptide (4-amino-acid peptide) derived from a pineal gland regulatory factor that is studied for its role in aging, telomerase activation, and longevity