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In addition to the aforementioned approaches, alternative routes of administration have been explored, including subcutaneous, intraperitoneal, and intravenous injection

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In a lipopolysaccharide (LPS)–induced endotoxemia mouse model, oral Mito-Apo markedly reduced systemic oxidative markers (e.g., 4-HNE) and preserved mitochondrial function, while standard apocynin showed minimal efficacy (Padhi et al., 2019)