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At the family level, the relative abundances of f_ Verrucomicrobiaceae , f_ Bacteroidaceae , and f_ Alcaligenaceae were increased and the relative abundances of f_ Lachnospiraceae and f_ Paraprevotellaceae were decreased in the butyrate group

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Treatment:3 Months

Results: In livers of humans and mice with MASH, AGXT was suppressed due to promoter hypermethylation, and LDHA activity was enhanced, leading to a marked increase in hepatic oxalate in association with disease severity