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S1P synthesis occurs by two isoforms of SK, SK1, and SK2, through adenosine triphosphate (ATP)-dependent phosphorylation of sphingosine, whereas its degradation occurs via two different pathways: the reversible dephosphorylation catalyzed by specific phosphatases (SGPP1 and SGPP2) and the irreversible cleavage by S1P lyase (SGPL)