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As indoleamine 2,3-dioxygenase (IDO) is a key enzyme for the degradation of trp in kyn, IDO activity is reflected in the trp/kyn (TKR) ratio

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In brief, polyphenols present a potentially effective therapeutic strategy for addressing neuroinflammation through their ability to modulate immunological responses, mitigate oxidative stress, and modulate crucial inflammatory signaling pathways (Dama et al., 2024)