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Using risk of Bias 2 to assess results from randomised controlled trials: guidance from Cochrane

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When used in conjunction with lactoferrin (Lf), its efficacy in penetrating the cerebral vasculature wall is significantly improve ( Deferiprone (DFP), an orally bioavailable iron binder, readily traverses the brain–blood partition ( 9.2 Lipid peroxidation inhibitor ACSL4 together with lipoxygenase isoforms fuel the fatty-acid oxidation cascade that powers ferroptosis, marking them as prime docking sites for anti-peroxidation agents

It favors its accumulation in the regions of high electron flux in cells where reactive species are generated.