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While the exact etiology of DILI remains unclear, several studies have indicated that the bioactivation of drugs to reactive metabolites, in conjunction with immune-related challenges, is one of significant contributing factors (Zhang and Tang, 2018)

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GSDMD is central to pyroptosis-induced inflammatory injury, so studies on the mechanisms regulating the conformation, transport, and pore-forming activity of GSDMD proteins are important for therapeutic targeting of inflammatory diseases (133)

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