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H 2 O 2 inhibits the activity of Krebs cycle enzymes such as aconitase, alpha-ketoglutarate dehydrogenase, and succinate dehydrogenase, which can collapse the mitochondrial proton gradient and affect the proton motive force required for pyruvate translocase to function in the inner mitochondrial membrane and transport pyruvate into the mitochondria

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The World Health Organization predicts it will be the third leading cause of death by 2030