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5.2.1 AMPK activation and improvement of metabolic homeostasis: metformin Metformin primarily exerts its pharmacological effects by activating AMPK and suppressing hepatic gluconeogenesis, thereby restoring glucose metabolic homeostasis

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FOXO/IIS/PI3K-AKT Signalling Pathway Forkhead box O (FOXO) transcription factors act downstream of the insulin/IGF-1 signalling (IIS) and phosphoinositide 3-kinase (PI3K)–protein kinase B (AKT) cascades