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STAR plays the central role of mediating the acute control of synthesis of steroid hormones by allowing the transport of cholesterol between the outer and inner mitochondrial membranes, where cholesterol side-chain cleavage occurs by P450scc ( Progesterone receptor (PGR) is a hormone that mediates the effects of progesterone that is essential in the establishment and maintenance of a mammalian pregnancy (49)

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Conversely, neuronal activity can restrain macrophage-driven inflammation, as demonstrated by cholinergic neuron-mediated suppression of macrophage activation in colitis model 174