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The results of this trial demonstrated that resveratrol intervention significantly reduced TNF-α and hs-CRP levels, suppressed NF-κB activity, and improved patients’ quality of life and clinical symptoms ( 6 Challenges and prospects 6.1 The complex interaction between bioavailability, metabolism, and intestinal pathology The clinical application of polyphenols is severely limited by their inherent characteristics, including chemical instability, low absorption rate in the gastrointestinal tract, and extensive and rapid metabolism by host enzymes and gut microbiota, resulting in generally low bioavailability of most polyphenols and significant individual differences