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Deregulation of CBS and the associated alterations in Hcy and/or H 2 S levels leads to a wide range of pathological disturbances in the cardiovascular, immune, and central nervous systems and contributes to disease development, such as CBS-deficient homocystinuria (CBSDH)

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In vivo , chronic treatment with opioids promotes decrease (down-regulation), no change or increase (up-regulation) of OR (Bernstein and Welch, 2001