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macaque data were integrated using SCTransform, FindIntegrationAnchors and IntegrateData with canonical correlation analysis (CCA) on the top 3,000 variable genes

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The metabolic activation of APAP is principally catalyzed by cytochrome P450 enzymes (17) and the reactive metabolite of greatest relevance for hepatotoxicity is generally believed to be N-acetyl-p-benzoquinone imine (NAPQI) (66)

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