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The FOXO4 peptide in a DRI conformation (D-amino acids in a retro-reversed sequence), henceforth named FOXO4-DRI, competes with FOXO4 for p53 binding in a dose-dependent manner and doing so with higher affinity.

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A commenter acknowledged CMS rationale for not including a rural adjustment but recommended that CMS monitor performance by geographic location and implement significant geographic adjustments to ensure rural practices are not disproportionately harmed and to account for rural healthcare challenges