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Effect of weight and maturation on busulfan clearance in infants and small children undergoing hematopoietic cell transplantation

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INTRODUCTION From 1982 to 1993, the Diabetes Control and Complications Trial (DCCT) was conducted in patients with type 1 diabetes mellitus (T1DM) to compare the effects of tightly controlled glycemia through intensive insulin therapy (IIT) versus moderately controlled glycemia through conventional insulin therapy (CIT) on long‐term secondary complications (Nathan, 2014)