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These include aziridines, 13 epoxides, 14 β-lactams, 15–17 squaramides 18,19 and diazirines, 20–22 which have seen specific applications related to their chemical reactivities, but which have largely precluded more general applications in medicinal chemistry: aziridines and epoxides have seen limited application due to their inherent electrophilic reactivity, although several drugs including thiotepa, mitomycin, eplerenone, fosfomycin, scopolamine and tiotropium do contain these rings, often as covalent antibiotics or alkylating agents

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