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These findings suggest that the combination of small molecule NNMT inhibitors with other nutritional supplements, such as the precursors of NAD + , may have the potential to enhance the efficacy of treatment for MetS and minimize the side effects caused by high pharmacological dosages ( In addition to MNAM and NNMTi, three new NAM analog inhibitors were reported for the treatment of MetS-related disorders in animal models: JBSNF-000088 ( JBSNF-000265 ( JBSNF-000028 ( JBSNF-000088 binds to the active site on NNMT and leads to the demethylation of SAM to SAH ( JBSNF-000028 ( JBSNF-000088 ( JBSNF-000265 was discovered through Structure-Activity Relationship (SAR) studies ( RS004 ( in vivo models has not been reported yet

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W., Thul, P., Czarnetzki, H