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DPYD GENOTYPING TO PREDICT SEVERE FLUOROPYRIMIDINE-RELATED TOXICITY We used severe fluoropyrimidine-related toxicity as the reference standard to calculate the sensitivity, specificity, PPV, and NPV of DPYD genotyping: that is, when toxicity was observed among carriers of a DPYD variant, it was considered a true positive finding, and when toxicity was not reported among non-carriers it was considered a true negative

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see Table 1) ( While European guidelines recommend up to 4 μg/day for adults, most of the included studies administered pharmacological doses ranging from hundreds to thousands of micrograms

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