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The aim of this study was to summarize the clinical characteristics of neonates with severe HEV leading to ALF in our centre, to provide evidence for further treatment and management

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SARS-CoV-2’s evolutionary rate has been estimated to be around 9’×’10 −4 substitutions per site per year [8], while also having a high transmissibility, large portion of asymptomatic cases [9], large pool of susceptible hosts to replicate in [10, 11], and on-going environmental pressures (e.g., low vaccination rates and changes in policies allowing human carriers to continue to transmit the virus), which have allowed SARS-CoV-2 to accumulate mutation in its genome