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An intermittent cold stress (ICS) fibromyalgia mouse model showed that 4-amino-3-(phenylselenyl)benzenesulfonamide (4-APSB), a selenium-sulfa compound with antioxidant properties reduces oxidative stress and neuroinflammation by activating NRF2, leading to enhanced antioxidant defense, lower IL-1β/TNF-α, and reduced pain and depressive-like behaviors (13)

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Clinical evidence consists of encouraging preclinical results and several early human trials demonstrating enhancements in fertility markers and outcomes, albeit with varying sample sizes and methodologies