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Glutaminolysis promotes nicotinamide adenine dinucleotide phosphate (NADPH) generation through glutamate dehydrogenase (GLUD)-mediated glutamate degradation, thereby contributing to ROS homeostasis 39

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In addition, LDR induced the expression of pro-inflammatory cytokines (IL-8, G-CSF, and platelet-derived growth factor-BB) in epithelial cells, which resulted in a microenvironment that is highly susceptible to inflammation (Meeren et al., 1997