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It shields the vulnerable N-terminal amine from proteolytic cleavage, drastically extends its half-life in the bloodstream, and allows for sustained receptor engagement without altering its binding affinity

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For example, TGF-β3 was physically loaded onto GO before being incorporated into a photopolymerizable poly-D, L-lactic acid/polyethylene glycol (PDLLA) hydrogel for chondrogenic differentiation [305]