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When produced excessively, it may suppress the release of Thyroid Stimulating Hormone from the pituitary.​ 18 ​ It also forces T4 to be converted to ‘reverse T3’ (rT3) which actually blocks thyroid function, even though thyroxine levels look adequate when tested.​ 19​ Blood glucose imbalance also triggers cortisol secretion, and insulin resistance may have a direct negative effect on the thyroid, too