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The testis is responsible for sperm production through spermatogenesis, a tightly regulated process that begins with spermatogonia and progresses through spermatocytes, spermatids, and spermatozoa (48, 49)

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Importantly, mitochondrial DNA (mtDNA) mutations, which accumulate with age and HTN, perpetuate this dysfunction, rendering the vasculature more susceptible to oxidative injury