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Treatment with DNA methyltransferases (DNMTs) inhibitor 5-aza-2′-deoxycytidine (5-Aza) and histone deacetylase (HDAC) inhibitor trichostatin A (TSA) has shown to restore the epigenetically silenced Nrf2 gene and increase NQO1 expression, which helps to prevent prostate cancer progression in TRAMP mice and protects against Alzheimer’s development in a mouse neuroblastoma N2a cellular model (Yu et al., 2010