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While the cytosolic GSH/thiol levels in the small-sized mutants, smt15-1 and GSH2 overexpressors, mirrored those of wild-type cells (accumulating during G1 and declining at early S/M phase), GSH/thiol was specifically accumulated in the basal bodies at early S/M phase in the small-sized mutants
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α-Syn over-expression or pre-formed-fibril seeding extends construct validity by reproducing Lewy pathology, yet fibril tropism and viral tropism vary widely between laboratories, yielding inconsistent timelines of synaptic failure, glial activation, and cell death [108]