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But one of the speculations as to why B12 supplements may cause breakouts is due to the fact that the supplements on store shelves contain unusually high amounts of B12

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For example, acute endurance exercise increased circulating mitochondrial-derived peptides in humans (Woodhead et al.), and a breast-cancer-survivor exercise study found changes in MOTS-c after a 16-week exercise program in one subgroup (Dieli-Conwright et al.)