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“Targeted inhibition of NNMT improves insulin responsiveness and may protect against diet-induced obesity.” — Hong et al., Nature Medicine ➤ Longevity and Anti-Aging Potential Because NAD⁺ is vital for DNA repair, circadian rhythm regulation, and mitochondrial health, 5-Amino-1MQ is being explored as a geroprotective agent — especially when stacked with NAD boosters or sirtuin activators