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The body’s antioxidant mechanisms, which include enzymatic systems such as superoxide dismutase (SOD), catalase, and glutathione peroxidase, along with non-enzymatic systems like reduced glutathione and vitamins A, C, and E, play critical roles in mitigating ROS damage (Honisch et al., 2023)

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Surgical decompression is the salvage option for patients who fail the conservative ladder — medication, image-guided block + steroid, hydrodissection, and pulsed RFA