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3T3-L1 cells were cultured in 60 mm diameter dishes (8.4 ⁇ 104 cells/dish) and treated with NNMT inhibitor dissolved in culture media with/without adipogenic factors (1 mM IBMX, 1 ⁇ M dexamethasone, 10 ⁇ g/ml of insulin) during each of the scheduled media changes during the differentiation process (described above)

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Mean reductions were 8.7%, 17.1%, 22.8%, and 24.2% for the 1, 4, 8, and 12 mg groups respectively, versus only 2.1% in the placebo arm