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Timing, the pattern of illness, the results of investigations, and rechallenging can help attribute causality to a suspected adverse drug reaction (ADR) [5]

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In the presence of Ca(II), the BAPTA carboxylate groups preferentially coordinate Ca(II), thereby allowing water molecules to coordinate the gadolinium(III) centers, which changes the hydration state per Gd(III) ion from q = 0 to q = 1