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Chloramphenicol is a potent inhibitor of cytochrome P450 isoforms CYP2C19 and CYP3A4 in human liver microsomes

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However, as we discussed DAM and DAA, it remains largely unclear how reactive astrocytes, which originate from the neuroectoderm, acquire functional similarities, such as inflammatory responses and phagocytic activity, to immune cells like microglia and macrophages that arise from primitive hematopoietic progenitors and mesoderm-derived bone marrow hematopoietic cells