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By replacing part of the ionizable lipids with adjuvant lipidoids, the researchers achieved not only enhanced mRNA delivery but also the acquisition of Toll-like receptor 7/8 (TLR7/8) agonistic activity, which resulted in a stronger innate immune response to the SARS-CoV-2 mRNA-LNP vaccine

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[DOI] [PubMed] [Google Scholar] 79.Meshul CK, Noguchi N, Emre N, Ellison G