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Cloning and production of IGF1Rzip The construct IGF1Rzip comprises a 30-residue signal peptide, followed in order by residues 1–905 of the intact IGF1 holoreceptor, a 33-residue leucine-zipper motif 61 , a three-residue spacer t, and an eleven-residue c-myc tag

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Mitochondrial Localization of mTORC1: Regulation of the Mitochondrial Oxidative Metabolism As described previously, mTORC1 regulates the translation of mitochondrial proteins encoded in the nucleus, however it is not the only function by which this important metabolic regulator acts