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The JAK2/STAT5 signaling pathway is activated after binding GH to its receptor, followed by transcriptional activation of IGF-1 synthesis and induction of SOCS proteins acting as a negative feedback loop ( vide supra )

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These findings, combined with the fact that Sirtuin’s deacetylase consumes NAD + , an essential redox signaling molecule, reminiscing the idea that Ergothioneine may affect Sirtuins’ activity through modulating NAD + availability