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In addition to pathway inhibitors, some pathway activators can also promote the reprogramming of M2 TAMs to anti-tumor M1 TAMs, such as nanoparticles Gd@C82 modified with β-alanine (GF-Ala) can be highly internalized by TAMs and reprogram TAMs from tumor-promoting M2 phenotype to tumor-killing M1 phenotype by activating NF-κB and IRF5 pathways thereby remodeling immunosuppressive TME, triggering effective anti-tumor immunity and effectively inhibiting tumor growth (49)