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98 DYRK1A was demonstrated to phosphorylate APP on Thr-668, which then facilitated the BACE1-mediated cleavage of APP, leading to an increase of Aβ

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Authors: Tiiu Kullisaar, Jelena Shepetova, Kersti Zilmer, Epp Songisepp, Aune Rehema, Marika Mikelsaar, Mihkel Zilmer Subjects: One hundred clinically healthy volunteers (75 females, 25 males, age 40-65 years) were recruited into a double-blind placebo-controlled randomized study