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When RNA therapeutics are applied in the brain, they are usually delivered to the CNS through intrathecal injections, ensuring adequate drug levels in disease-relevant areas by circumventing the BBB (Holm et al., 2022)

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Increased levels of ROS, MDA, and AOPP have been observed in both naturally and experimentally infected dogs [144,145,146,147,149,151], while a decrease in nitric oxide (NO) and MDA was noted following doxycycline treatment [149]