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In healthy mitochondria, progerin-associated rhodopsin-like (PARL) proteases and matrix processing peptidase (MPP) degrade PINK1 [82]

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Indeed, the HPA axis activity is characterized not only by a typical circadian rhythm, but also by an ultradian pattern of discrete pulsatile release of glucocorticoids, with a pulse of production every 1-2 hours [56]