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2.6.1.5 Effects of SL on liver fibrosis A team of Chinese researchers reported that SL inhibited HSC activation and hepatic apoptosis and prevented the formation of mallory-denk bodies in the NASH liver when SL was orally administered to the male C57BL/6 mice which were fed a MCD diet for 8 weeks, and the effect was related to alteration of lipid metabolism-related gene expression, activation of the Nrf2 pathway and inhibition of the NF-κB signaling pathway in the NASH liver (Ou et al., 2018)

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Postmortem results show increased TLR4 protein expression in the prefrontal cortex of schizophrenia patients (152), which is associated with activation of the MyD88 and NF-κB pathways (156)

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