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Disclosures: Shreeya Thussu: Nothing to Disclose, Spyridon Zouridis: Nothing to Disclose, Kamran Qureshi: Phathom Pharmaceuticals: Speaking and Teaching, Intercept Pharmaceuticals: Speaking and Teaching, Gilead Sciences: Speaking and Teaching, Salix Pharmaceuticals: Speaking and Teaching, Madrigal Pharmaceuticals: Speaking and Teaching 2387 HLX92, A NEW MOLECULAR ENTITY TARGETING GUT MICROBIOTA–LIVER AXIS, CONFERS THERAPEUTIC POTENTIAL AGAINST CHOLESTATIC LIVER DISEASES Guan-Zhen Wang 1 Teng Feng 1 Li-Ping Han 1 Zhi-Liang Lv 1 Ji-Chen Sha 1 Xiao-Ling Yuan 1 Long-Ling Li 1 Yong-Qiang Shan 1 , 1 Shanghai Henlius Biotech, Inc